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CS-W001157 4
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6-Bromo-2-methylpyrazolo[1,5-a]pyrimidine

  • CAS No. 916256-65-0

  • Cat. No. CS-0050290
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2-methylpyrazolo[1,5-a]pyrimidine|CS-0050290

Structure of 916256-65-0

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General Information

  • CAS No. 916256-65-0
  • Cat. No. CS-0050290
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrN₃
  • Molecular Weight 212.05
  • Synonym(s) None
  • SMILES CC1=NN2C=C(Br)C=NC2=C1

Description

6-Bromo-2-methylpyrazolo[1,5-a]pyrimidine features a fused heterocyclic core with bromine at the 6-position and a methyl group at the 2-position, enabling selective functionalization in medicinal chemistry. The electron-deficient pyrimidine ring facilitates cross-coupling reactions, while the steric profile supports regioselective derivatization. This scaffold serves as a key building block for kinase inhibitors and bioactive nitrogen-rich compounds.

Application

6-Bromo-2-methylpyrazolo[1,5-a]pyrimidine serves as a versatile building block for heterocyclic synthesis, enabling efficient construction of pyrazolo[1,5-a]pyrimidine-based scaffolds. The bromine at C6 facilitates palladium-catalyzed cross-coupling reactions, while the methyl group at C2 enhances regioselectivity and metabolic stability. Its bench-stable nature and compatibility with diverse functional groups make it ideal for medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   1.80022
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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