2,4-Dichloro-7,7-dimethyl-5H-furo[3,4-d]pyrimidine

Name: 2,4-Dichloro-7,7-dimethyl-5H-furo[3,4-d]pyrimidine
Brand: ChemScene
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CAS No. 1260088-72-9
Cat. No. CS-0036672
Purity≥97%
MDL No.None

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2,4-Dichloro-7,7-dimethyl-5H-furo[3,4-d]pyrimidine|CS-0036672

Structure of 1260088-72-9

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General Information

CAS No. 1260088-72-9
Cat. No. CS-0036672
Purity ≥97%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈Cl₂N₂O
Molecular Weight 219.07
Synonym(s) 2,4-Dichloro-7,7-dimethyl-5,7-dihydrofuro[3,4-d]pyrimidine
SMILES CC1(C)C2=C(CO1)C(=NC(=N2)Cl)Cl

Description

This furo[3,4-d]pyrimidine scaffold features two chlorine substituents at the 2 and 4 positions and two methyl groups flanking the central ring junction, delivering a sterically congested, electron-deficient core ideal for coupling reactions in medicinal chemistry and materials synthesis.

Application

2,4-Dichloro-7,7-dimethyl-5H-furo[3,4-d]pyrimidine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to fused pyrimidine scaffolds via nucleophilic substitution. Its dichloro functionality offers predictable reactivity at C2 and C4 positions, facilitating coupling with amines, alcohols, and thiols under mild conditions. The 7,7-dimethyl substitution enhances bench stability and simplifies purification. This compound functions as a key intermediate in the construction of biologically relevant frameworks, particularly in medicinal chemistry campaigns targeting kinase inhibitors and antiviral agents.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 35.01
LogP 2.5487
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydrofuran compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2,4-Dichloro-7,7-dimethyl-5H-furo[3,4-d]pyrimidine

CAS No. 1260088-72-9

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