4-(1-((tert-Butoxycarbonyl)amino)cyclobutyl)benzoic acid

Name: 4-(1-((tert-Butoxycarbonyl)amino)cyclobutyl)benzoic acid
Brand: ChemScene
Availability: InStock
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CAS No. 1259223-99-8
Cat. No. CS-0154443
Purity≥98%
MDL No.MFCD18762016

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-(1-((tert-Butoxycarbonyl)amino)cyclobutyl)benzoic acid|CS-0154443

Structure of 1259223-99-8

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Description

This cyclobutyl-substituted benzoic acid features a tert-butoxycarbonyl-protected amine, enabling straightforward incorporation into peptide synthesis. The rigid cyclobutyl ring imparts conformational stability, while the carboxylic acid group facilitates coupling reactions under standard conditions.

Application

4-(1-((tert-Butoxycarbonyl)amino)cyclobutyl)benzoic acid serves as a versatile building block for medicinal chemistry and peptide conjugation, enabling the synthesis of cyclobutyl-containing bioactive molecules. The tert-butyl carbamate (Boc) group provides excellent stability during synthetic manipulations and can be selectively removed under mild acidic conditions. The carboxylic acid functionality facilitates coupling reactions with amines or alcohols, while the cyclobutyl ring imparts conformational rigidity beneficial for structure-activity studies.

General Information

CAS No. 1259223-99-8
Cat. No. CS-0154443
Purity ≥98%
MDL No. MFCD18762016
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₂₁NO₄
Molecular Weight 291.34
Synonym(s) None
SMILES CC(C)(OC(NC1(C2=CC=C(C(O)=O)C=C2)CCC1)=O)C

Computational Chemistry Data

TPSA 75.63
LogP 3.2887
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Key Words

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4-(1-((tert-Butoxycarbonyl)amino)cyclobutyl)benzoic acid

CAS No. 1259223-99-8

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