6-(Difluoromethyl)pyridine-2-carboxylicacid

Name: 6-(Difluoromethyl)pyridine-2-carboxylicacid
Brand: ChemScene
Availability: InStock
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CAS No. 1256824-41-5
Cat. No. CS-0309801
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-(Difluoromethyl)pyridine-2-carboxylicacid|CS-0309801

Structure of 1256824-41-5

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General Information

CAS No. 1256824-41-5
Cat. No. CS-0309801
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅F₂NO₂
Molecular Weight 173.12
Synonym(s) 6-(Difluoromethyl)pyridine-2-carboxylic acid
SMILES OC(=O)C1=CC=CC(=N1)C(F)F

Description

6-(Difluoromethyl)pyridine-2-carboxylic acid features a pyridine core functionalized with both a difluoromethyl group and a carboxylic acid at adjacent positions, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables direct incorporation into bioactive scaffolds requiring polar, lipophilic motifs with resistance to oxidative degradation.

Application

6-(Difluoromethyl)pyridine-2-carboxylic acid serves as a valuable building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethyl group adjacent to a pyridine carboxylic acid scaffold. Its functional groups facilitate direct coupling reactions, including amide formation and esterification, with excellent bench stability and compatibility in standard synthetic workflows.

Synthesis

Route1
- In-stock
  
  1379375-24-2
- ~64%
- In-stock
  
  1256824-41-5
References
- WO2012/68450 A1, ; Page/Page column 112 ; WO 2012/068450 A1
Route2
- In-stock
  
  69950-65-8
- ~%
- In-stock
  
  1256824-41-5
References
- WO2012/68450 A1, ; WO 2012/068450 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 50.19
LogP 1.7174
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-(Difluoromethyl)pyridine-2-carboxylicacid

CAS No. 1256824-41-5

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