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CS-W001157 4
Total: USD 88.00

2-[3-(trifluoromethyl)-1h-pyrazol-1-yl]acetic acid

  • CAS No. 926241-24-9

  • Cat. No. CS-0220708
  • Purity≥95%
  • MDL No.MFCD04969231

*For research and further manufacturing use only, not for direct human use.

2-[3-(trifluoromethyl)-1h-pyrazol-1-yl]acetic acid|CS-0220708

Structure of 926241-24-9

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General Information

  • CAS No. 926241-24-9
  • Cat. No. CS-0220708
  • Purity ≥95%
  • MDL No. MFCD04969231
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅F₃N₂O₂
  • Molecular Weight None
  • Synonym(s) [3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid
  • SMILES C1=CN(CC(=O)O)N=C1C(F)(F)F

Description

This trifluoromethyl-substituted pyrazole acetic acid integrates a polar carboxylate handle with enhanced electron-withdrawing character from the trifluoromethyl group, enabling efficient conjugation and solubility in aqueous-organic mixtures.

Application

2-[3-(Trifluoromethyl)-1H-pyrazol-1-yl]acetic acid serves as a versatile building block for medicinal chemistry, enabling the introduction of a polar, electron-deficient trifluoromethylpyrazole moiety adjacent to a carboxylic acid. The molecule exhibits bench stability and facilitates direct coupling reactions, including amide formation and esterification, with high functional group tolerance. Its utility is well-established in constructing bioactive scaffolds, particularly in kinase inhibitor and CNS-targeted compound development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.9865
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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