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CS-W001157 4
Total: USD 88.00

5,6,7,8-Tetrahydroquinoline-6-carboxylic acid

  • CAS No. 1256822-12-4

  • Cat. No. CS-0187082
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydroquinoline-6-carboxylic acid|CS-0187082

Structure of 1256822-12-4

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General Information

  • CAS No. 1256822-12-4
  • Cat. No. CS-0187082
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO₂
  • Molecular Weight 177.20
  • Synonym(s) None
  • SMILES C1=CC2=C(CCC(C2)C(=O)O)N=C1

Description

5,6,7,8-Tetrahydroquinoline-6-carboxylic acid features a saturated quinoline core with a carboxylic acid at the 6-position, offering enhanced solubility and stability compared to aromatic analogs. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds, where its lipophilic character and hydrogen-bonding capacity support target engagement.

Application

5,6,7,8-Tetrahydroquinoline-6-carboxylic acid serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functional group transformations. Its carboxylic acid moiety facilitates direct coupling reactions and derivatization, while the saturated ring system offers enhanced metabolic stability and favorable pharmacokinetic properties. Bench-stable and amenable to purification by recrystallization or chromatography, it functions as a key building block in the synthesis of targeted small molecules and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.2711
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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