6-Chloro-5-fluoropyridin-3-amine

Name: 6-Chloro-5-fluoropyridin-3-amine
Brand: ChemScene
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CAS No. 1256806-83-3
Cat. No. CS-W006372
Purity≥95%
MDL No.MFCD18257897

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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6-Chloro-5-fluoropyridin-3-amine|CS-W006372

Structure of 1256806-83-3

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General Information

CAS No. 1256806-83-3
Cat. No. CS-W006372
Purity ≥95%
MDL No. MFCD18257897
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClFN₂
Molecular Weight 146.55
Synonym(s) None
SMILES NC1=CC(F)=C(Cl)N=C1

Description

6-Chloro-5-fluoropyridin-3-amine features a trifluorinated pyridine core with orthogonal halogen substituents enabling selective cross-coupling. The electron-deficient heterocycle pairs effectively with palladium catalysts, while the primary amine group facilitates direct functionalization. This scaffold delivers high reactivity under standard conditions and exhibits bench-stable handling characteristics.

Application

6-Chloro-5-fluoropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of fluorinated heterocyclic scaffolds. Its dual halogen functionality supports palladium-catalyzed cross-coupling reactions, while the primary amine facilitates derivatization via acylation, alkylation, or reductive amination. The compound exhibits good bench stability and compatibility with standard synthetic workflows, making it a practical choice for the synthesis of kinase inhibitors and other bioactive molecules.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 1.4563
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-5-fluoropyridin-3-amine

CAS No. 1256806-83-3

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