2-Chloro-6-methoxyisonicotinonitrile

Name: 2-Chloro-6-methoxyisonicotinonitrile
Brand: ChemScene
Availability: InStock
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CAS No. 1256788-36-9
Cat. No. CS-0373246
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-6-methoxyisonicotinonitrile|CS-0373246

Structure of 1256788-36-9

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Description

2-Chloro-6-methoxyisonicotinonitrile features a strategically positioned nitrile group and electron-withdrawing chlorine, enabling efficient coupling in heterocyclic synthesis. The methoxy substituent enhances solubility and modulates reactivity under standard conditions. This bench-stable building block facilitates access to functionalized pyridine scaffolds in medicinal chemistry and materials development.

Application

2-Chloro-6-methoxyisonicotinonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based heterocycles. Its ortho-chloro and nitrile groups facilitate palladium-catalyzed cross-coupling reactions and nucleophilic substitution, while the methoxy substituent enhances solubility and modulates electronic properties. The compound exhibits excellent bench stability and is compatible with standard synthetic workflows, making it ideal for rapid diversification in API lead optimization.

General Information

CAS No. 1256788-36-9
Cat. No. CS-0373246
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClN₂O
Molecular Weight 168.58
Synonym(s) None
SMILES N#CC1=CC(Cl)=NC(OC)=C1

Computational Chemistry Data

TPSA 45.91
LogP 1.61528
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-6-methoxyisonicotinonitrile

CAS No. 1256788-36-9

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