2-Chloro-6-methoxy-4-methylpyridine

Name: 2-Chloro-6-methoxy-4-methylpyridine
Brand: ChemScene
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CAS No. 25297-52-3
Cat. No. CS-W007131
Purity≥97%
MDL No.MFCD16610595

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-6-methoxy-4-methylpyridine|CS-W007131

Structure of 25297-52-3

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General Information

CAS No. 25297-52-3
Cat. No. CS-W007131
Purity ≥97%
MDL No. MFCD16610595
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈ClNO
Molecular Weight 157.60
Synonym(s) Pyridine, 2-chloro-6-Methoxy-4-Methyl-
SMILES CC1=CC(Cl)=NC(OC)=C1

Description

2-Chloro-6-methoxy-4-methylpyridine features a pyridine core functionalized with chlorine, methoxy, and methyl groups at the 2-, 6-, and 4-positions respectively. This electron-deficient heterocycle serves as a key intermediate in medicinal chemistry, enabling direct coupling reactions due to its regioselective reactivity. The methoxy group enhances solubility and modulates electronic properties, while the methyl substituent adds steric bulk. The compound exhibits bench-stable handling under standard conditions.

Application

2-Chloro-6-methoxy-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The ortho-chloro group facilitates selective substitution, while the methoxy and methyl substituents provide steric and electronic modulation. Its bench stability and compatibility with diverse reaction conditions make it well-suited for constructing complex heterocyclic scaffolds in API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 22.12
LogP 2.05202
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-6-methoxy-4-methylpyridine

CAS No. 25297-52-3

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