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CS-W001157 4
Total: USD 88.00

3-(Trifluoromethyl)-1H-pyrazol-4-amine

  • CAS No. 1248452-50-7

  • Cat. No. CS-0080489
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Trifluoromethyl)-1H-pyrazol-4-amine|CS-0080489

Structure of 1248452-50-7

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General Information

  • CAS No. 1248452-50-7
  • Cat. No. CS-0080489
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄F₃N₃
  • Molecular Weight 151.09
  • Synonym(s) None
  • SMILES FC(F)(F)C1=NNC=C1N

Description

3-(Trifluoromethyl)-1H-pyrazol-4-amine features a trifluoromethyl group at the 3-position and an amine function at the 4-position of the pyrazole ring, conferring enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and bioactive heterocycles. The compound exhibits bench-stable handling and favorable solubility profiles under standard conditions.

Application

3-(Trifluoromethyl)-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through palladium-catalyzed couplings and electrophilic substitutions. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the pyrazole amine functionality offers site-specific derivatization for drug discovery applications. The compound exhibits good bench stability and facilitates straightforward purification, supporting scalable synthesis in API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.0107
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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