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CS-W001157 4
Total: USD 88.00

1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-amine

  • CAS No. 1006436-44-7

  • Cat. No. CS-W019098
  • Purity≥98%
  • MDL No.MFCD04970058

*For research and further manufacturing use only, not for direct human use.

1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-amine|CS-W019098

Structure of 1006436-44-7

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General Information

  • CAS No. 1006436-44-7
  • Cat. No. CS-W019098
  • Purity ≥98%
  • MDL No. MFCD04970058
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆F₃N₃
  • Molecular Weight 165.12
  • Synonym(s) 3-(Trifluoromethyl)-1-methyl-1H-pyrazol-4-amine
  • SMILES NC1=CN(C)N=C1C(F)(F)F

Description

1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-amine features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the methylated pyrazole core provides improved solubility and synthetic handle. This scaffold integrates readily into bioactive molecules, particularly in kinase inhibitor design and agrochemical development.

Application

1-Methyl-3-(trifluoromethyl)-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyrazole core provides a robust scaffold for Suzuki-Miyaura and Buchwald-Hartwig couplings. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and process development in API discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.0211
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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