Lot numbers can be found on the outside label of a product:
5-(Trifluoromethyl)-3-pyridinamine
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CAS No. 112110-07-3
- Cat. No. CS-W008860
- Purity≥97%
- MDL No.MFCD00128900
*For research and further manufacturing use only, not for direct human use.
Structure of 112110-07-3
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General Information
- CAS No. 112110-07-3
- Cat. No. CS-W008860
- Purity ≥97%
- MDL No. MFCD00128900
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₅F₃N₂
- Molecular Weight 162.11
- Synonym(s) 3-Amino-5-trifluoromethylpyridine; 5-(Trifluoromethyl)pyridin-3-ylamine; 5-Trifluoromethyl-3-aminopyridine; 5-Trifluoromethyl-pyridin-3-ylamine
- SMILES NC1=CC(C(F)(F)F)=CN=C1
Description
5-(Trifluoromethyl)-3-pyridinamine features a trifluoromethyl group at the 5-position of a pyridine ring, enhancing electron-withdrawing character and metabolic stability. This nitrogen-rich scaffold integrates readily into pharmaceutical intermediates and functional materials, offering improved solubility and reactivity in cross-coupling transformations under standard conditions.
Application
5-(Trifluoromethyl)-3-pyridinamine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized heterocycles via Pd-catalyzed cross-coupling and electrophilic substitution. The trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the pyridinamine moiety provides a reactive site for derivatization. Its bench-stable nature and compatibility with standard reaction conditions facilitate straightforward incorporation into API scaffolds and advanced synthetic intermediates.
Synthesis
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Route1
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In-stock
85148-26-1 - ~96%
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In-stock
112110-07-3
References
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Organic Letters, , vol. 15, # 14 p. 3734 - 3737
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Route2
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In-stock
72587-15-6 - ~7%
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In-stock
112110-07-3
References
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WO2008/79965 A1, ; Page/Page column 72-73 ;
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Route3
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1529769-93-4 - ~88%
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In-stock
112110-07-3
References
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WO2014/418 A1, ; Page/Page column 83 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.91
- LogP 1.6826
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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