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CS-W001157 4
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1-(Boc)-5-Fluoropiperidine-3-carboxylic acid

  • CAS No. 1241725-64-3

  • Cat. No. CS-W001355
  • Purity≥97%
  • MDL No.MFCD17015060

*For research and further manufacturing use only, not for direct human use.

1-(Boc)-5-Fluoropiperidine-3-carboxylic acid|CS-W001355

Structure of 1241725-64-3

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General Information

  • CAS No. 1241725-64-3
  • Cat. No. CS-W001355
  • Purity ≥97%
  • MDL No. MFCD17015060
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₈FNO₄
  • Molecular Weight 247.26
  • Synonym(s) 1-(Tert-Butoxycarbonyl)-5-Fluoropiperidine-3-Carboxylic Acid
  • SMILES FC1CC(CN(C1)C(=O)OC(C)(C)C)C(=O)O

Description

1-(Boc)-5-Fluoropiperidine-3-carboxylic acid features a fluorinated piperidine core with a Boc-protected carboxylic acid, enabling direct incorporation into peptide and small-molecule scaffolds. The electron-withdrawing fluorine enhances metabolic stability, while the bench-stable Boc group simplifies handling and subsequent deprotection under standard conditions.

Application

1-(Boc)-5-Fluoropiperidine-3-carboxylic acid serves as a versatile building block for the synthesis of fluorinated piperidine-containing scaffolds prevalent in medicinal chemistry. The Boc group provides excellent stability and ease of removal under mild acidic conditions, enabling straightforward functionalization. The molecule exhibits robust compatibility with standard coupling reactions and facilitates efficient access to complex heterocyclic systems through orthogonal transformations.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.6661
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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