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CS-W001157 4
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4-(Azetidin-3-yl)pyridine dihydrochloride

  • CAS No. 1236791-32-4

  • Cat. No. CS-0139696
  • Purity≥97%
  • MDL No.MFCD20528835

*For research and further manufacturing use only, not for direct human use.

4-(Azetidin-3-yl)pyridine dihydrochloride|CS-0139696

Structure of 1236791-32-4

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General Information

  • CAS No. 1236791-32-4
  • Cat. No. CS-0139696
  • Purity ≥97%
  • MDL No. MFCD20528835
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂Cl₂N₂
  • Molecular Weight 207.10
  • Synonym(s) 4-(azetidin-3-yl)pyridine dihydrochloroide
  • SMILES [H]Cl.[H]Cl.C1(C2CNC2)=CC=NC=C1

Description

4-(Azetidin-3-yl)pyridine dihydrochloride features a pyridine core linked to a sterically constrained azetidine ring, delivering enhanced solubility and metabolic stability. This configuration enables efficient integration into medicinal chemistry scaffolds, particularly in kinase inhibitor development. The dihydrochloride salt form ensures excellent crystallinity and handling under standard bench conditions.

Application

4-(Azetidin-3-yl)pyridine dihydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles. The azetidine moiety provides enhanced solubility and metabolic stability, while the pyridine core offers tunable basicity and hydrogen-bonding capacity. This compound facilitates rapid diversification via nucleophilic substitution and palladium-catalyzed coupling reactions, with excellent bench stability and straightforward purification, making it ideal for high-throughput synthesis campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.612
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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