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CS-W001157 4
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1-(Benzo[b]thiophen-4-yl)piperazine hydrochloride

  • CAS No. 913614-18-3

  • Cat. No. CS-0028119
  • Molecule weight254.78
  • Purity≥95%
  • MDL No.MFCD26743820

*For research and further manufacturing use only, not for direct human use.

1-(Benzo[b]thiophen-4-yl)piperazine hydrochloride|CS-0028119

Structure of 913614-18-3

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General Information

  • CAS No. 913614-18-3
  • Cat. No. CS-0028119
  • Purity ≥95%
  • MDL No. MFCD26743820
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅ClN₂S
  • Molecular Weight 254.78
  • Synonym(s) Piperazine, 1-benzo[b]thien-4-yl-, hydrochloride
  • SMILES [H]Cl.N1(C2=C(C=CS3)C3=CC=C2)CCNCC1

Description

This piperazine derivative features a benzo[b]thiophene core linked to a piperazine moiety, delivering enhanced solubility and metabolic stability. The hydrochloride salt form ensures improved crystallinity and handling. Designed for medicinal chemistry applications, it integrates readily into kinase inhibitor scaffolds and offers favorable pharmacokinetic properties in preclinical development.

Application

1-(Benzo[b]thiophen-4-yl)piperazine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its benzo[b]thiophene core provides enhanced metabolic stability and π-stacking potential, while the piperazine moiety offers tunable solubility and hydrogen-bonding capacity. The hydrochloride salt ensures excellent crystallinity and shelf stability, facilitating straightforward handling and purification in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   2.7327
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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