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CS-W001157 4
Total: USD 88.00

7-Bromo-1H-indazol-3-amine

  • CAS No. 1234616-28-4

  • Cat. No. CS-W006669
  • Purity≥98%
  • MDL No.MFCD12406137

*For research and further manufacturing use only, not for direct human use.

7-Bromo-1H-indazol-3-amine|CS-W006669

Structure of 1234616-28-4

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General Information

  • CAS No. 1234616-28-4
  • Cat. No. CS-W006669
  • Purity ≥98%
  • MDL No. MFCD12406137
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrN₃
  • Molecular Weight 212.05
  • Synonym(s) 7-Bromo-1H-indazol-3-ylamine
  • SMILES BrC1=CC=CC2=C1NN=C2N

Description

7-Bromo-1H-indazol-3-amine features a brominated indazole core with a primary amine at the 3-position, enabling direct coupling in cross-coupling reactions. The electron-deficient aromatic system enhances reactivity in palladium-catalyzed transformations, while the bench-stable crystalline form facilitates handling and purification under standard conditions.

Application

7-Bromo-1H-indazol-3-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the indazole core via palladium-catalyzed cross-coupling reactions. The bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the primary amine functionality offers site-specific derivatization for peptide-like conjugations or heterocycle elaboration. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses of kinase inhibitors and other bioactive scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.9076
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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