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CS-W001157 4
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3-Bromo-6-fluoro-2-pyridinamine

  • CAS No. 1232431-41-2

  • Cat. No. CS-0040533
  • Purity≥96%
  • MDL No.MFCD16556245

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-fluoro-2-pyridinamine|CS-0040533

Structure of 1232431-41-2

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General Information

  • CAS No. 1232431-41-2
  • Cat. No. CS-0040533
  • Purity ≥96%
  • MDL No. MFCD16556245
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BrFN₂
  • Molecular Weight 191.00
  • Synonym(s) 3-Bromo-6-fluoropyridin-2-amine
  • SMILES NC1=NC(F)=CC=C1Br

Description

3-Bromo-6-fluoro-2-pyridinamine features a strategically positioned bromo and fluoro substitution on the pyridine ring, enabling directed metalation and cross-coupling reactions. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and functional materials, offering enhanced reactivity under standard conditions.

Application

3-Bromo-6-fluoro-2-pyridinamine serves as a versatile building block for the synthesis of bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions due to its compatible halogen functionality. The ortho-amino group facilitates directed metallation and further functionalization, while the fluorine substituent enhances metabolic stability and modulates electronic properties in pharmaceutical scaffolds. Bench-stable and amenable to standard purification techniques, it functions effectively in multi-step synthetic sequences requiring precise regiocontrol.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.5654
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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