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(R)-2-Methylpyrrolidine-2-carboxylic acid hydrochloride

  • CAS No. 123053-48-5

  • Cat. No. CS-M3406
  • Molecule weight165.62
  • Purity≥97%
  • MDL No.MFCD20487714

*For research and further manufacturing use only, not for direct human use.

(R)-2-Methylpyrrolidine-2-carboxylic acid hydrochloride|CS-M3406

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General Information

  • CAS No. 123053-48-5
  • Cat. No. CS-M3406
  • Purity ≥97%
  • MDL No. MFCD20487714
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClNO₂
  • Molecular Weight 165.62
  • Synonym(s) D-Proline,2-methyl-,hydrochloride
  • SMILES O=C(O)[C@]1(C)NCCC1.[H]Cl

Description

(R)-2-Methylpyrrolidine-2-carboxylic acid hydrochloride features a chiral pyrrolidine core with a methyl group at the 2-position, delivering enhanced conformational rigidity. This bench-stable derivative serves as a privileged scaffold in medicinal chemistry, integrating readily into peptidomimetics and bioactive molecule frameworks.

Application

(R)-2-Methylpyrrolidine-2-carboxylic acid hydrochloride serves as a stereochemically defined building block for the synthesis of peptidomimetics and bioactive heterocycles. Its chiral pyrrolidine core exhibits enhanced metabolic stability and conformational rigidity, enabling efficient incorporation into pharmaceutical scaffolds. The hydrochloride salt ensures excellent bench stability, solubility in polar solvents, and ease of handling during solid-phase and solution-phase synthesis. Functions effectively in amide coupling, cyclization, and metal-catalyzed transformations.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   0.6349
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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