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(S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride

  • CAS No. 1508261-86-6

  • Cat. No. CS-M1378
  • Purity≥95%
  • MDL No.MFCD04115802

*For research and further manufacturing use only, not for direct human use.

(S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride|CS-M1378

Structure of 1508261-86-6

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General Information

  • CAS No. 1508261-86-6
  • Cat. No. CS-M1378
  • Purity ≥95%
  • MDL No. MFCD04115802
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClNO₂
  • Molecular Weight 165.62
  • Synonym(s) 2-Methyl-L-proline hydrochloride; 2-Methyl-L-proline HCl
  • SMILES O=C(O)[C@]1(NCCC1)C.Cl

Description

(S)-2-methylpyrrolidine-2-carboxylic acid hydrochloride is a chiral building block featuring a sterically hindered, bench-stable pyrrolidine core with a defined (S)-configuration. This configuration imparts high enantioselectivity in asymmetric synthesis, enabling precise incorporation into peptidomimetics and bioactive scaffolds. The hydrochloride salt enhances solubility and handling stability, facilitating use in solid-phase peptide coupling and medicinal chemistry workflows.

Application

(S)-2-Methylpyrrolidine-2-carboxylic acid hydrochloride serves as a stereochemically defined building block for the synthesis of peptidomimetics and bioactive heterocycles. Its chiral, N-protected form enables efficient incorporation into peptide backbones via standard coupling protocols. The hydrochloride salt enhances bench stability and simplifies purification, while the tertiary α-carbon supports diverse functionalization strategies in medicinal chemistry campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   0.6349
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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