2-Boc-2,7-diazaspiro[4.5]decan-6-one

Name: 2-Boc-2,7-diazaspiro[4.5]decan-6-one
Brand: ChemScene
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CAS No. 1228631-64-8
Cat. No. CS-W001349
Purity≥97%
MDL No.MFCD16618554

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Boc-2,7-diazaspiro[4.5]decan-6-one|CS-W001349

Structure of 1228631-64-8

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Description

2-Boc-2,7-diazaspiro[4.5]decan-6-one is a sterically shielded spirocyclic ketone featuring a protected diamine core, enabling direct incorporation into complex alkaloid scaffolds. The Boc group ensures stability during synthesis and facilitates selective deprotection under mild acidic conditions. This scaffold provides a rigid, three-dimensional platform for medicinal chemistry optimization, particularly in CNS-targeted compound libraries.

Application

2-Boc-2,7-diazaspiro[4.5]decan-6-one serves as a versatile spirocyclic scaffold for medicinal chemistry and catalytic synthesis, offering a rigid, stereochemically defined core with orthogonal functional handles. The Boc group enables stable protection of the secondary amine, facilitating selective deprotection and downstream derivatization. Its compatibility with standard coupling reactions, robust bench stability, and utility in constructing nitrogen-rich heterocycles make it a practical building block for API intermediates and macrocyclic ligands.

General Information

CAS No. 1228631-64-8
Cat. No. CS-W001349
Purity ≥97%
MDL No. MFCD16618554
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₂N₂O₃
Molecular Weight 254.33
Synonym(s) 2,7-Diazaspiro[4.5]decane-2-carboxylic acid, 6-oxo-, 1,1-dimethylethyl ester
SMILES O=C(N1CCC2(C1)CCCNC2=O)OC(C)(C)C

Computational Chemistry Data

TPSA 58.64
LogP 1.5236
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

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2-Boc-2,7-diazaspiro[4.5]decan-6-one

CAS No. 1228631-64-8

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