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CS-W001157 4
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2-Boc-2,7-diazaspiro[4.5]decan-6-one

  • CAS No. 1228631-64-8

  • Cat. No. CS-W001349
  • Molecule weight254.33
  • Purity≥97%
  • MDL No.MFCD16618554

*For research and further manufacturing use only, not for direct human use.

2-Boc-2,7-diazaspiro[4.5]decan-6-one|CS-W001349

Structure of 1228631-64-8

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General Information

  • CAS No. 1228631-64-8
  • Cat. No. CS-W001349
  • Purity ≥97%
  • MDL No. MFCD16618554
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₂N₂O₃
  • Molecular Weight 254.33
  • Synonym(s) 2,7-Diazaspiro[4.5]decane-2-carboxylic acid, 6-oxo-, 1,1-dimethylethyl ester
  • SMILES O=C(N1CCC2(C1)CCCNC2=O)OC(C)(C)C

Description

2-Boc-2,7-diazaspiro[4.5]decan-6-one is a sterically shielded spirocyclic ketone featuring a protected diamine core, enabling direct incorporation into complex alkaloid scaffolds. The Boc group ensures stability during synthesis and facilitates selective deprotection under mild acidic conditions. This scaffold provides a rigid, three-dimensional platform for medicinal chemistry optimization, particularly in CNS-targeted compound libraries.

Application

2-Boc-2,7-diazaspiro[4.5]decan-6-one serves as a versatile spirocyclic scaffold for medicinal chemistry and catalytic synthesis, offering a rigid, stereochemically defined core with orthogonal functional handles. The Boc group enables stable protection of the secondary amine, facilitating selective deprotection and downstream derivatization. Its compatibility with standard coupling reactions, robust bench stability, and utility in constructing nitrogen-rich heterocycles make it a practical building block for API intermediates and macrocyclic ligands.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   58.64
  • LogP   1.5236
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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