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1,8-Diazaspiro[4.5]decan-2-one hydrochloride

  • CAS No. 1389313-57-8

  • Cat. No. CS-0052717
  • Molecule weight190.67
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,8-Diazaspiro[4.5]decan-2-one hydrochloride|CS-0052717

Structure of 1389313-57-8

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General Information

  • CAS No. 1389313-57-8
  • Cat. No. CS-0052717
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅ClN₂O
  • Molecular Weight 190.67
  • Synonym(s) 1,8-DIAZASPIRO[4.5]DECAN-2-ONE HCL
  • SMILES Cl.O=C1CCC2(CCNCC2)N1

Description

1,8-Diazaspiro[4.5]decan-2-one hydrochloride features a rigid spirocyclic scaffold with dual nitrogen atoms positioned for enhanced hydrogen bonding and polarity. This bench-stable salt form improves solubility in aqueous media while maintaining structural integrity under standard handling conditions. The compound serves as a key building block in the synthesis of bioactive heterocycles and functionalized scaffolds.

Application

1,8-Diazaspiro[4.5]decan-2-one hydrochloride serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through well-established transformations. Its spirocyclic architecture provides defined stereochemistry and rigidity, while the protected amine and ketone functionalities offer orthogonal reactivity for sequential functionalization. The hydrochloride salt enhances solubility and stability, facilitating handling and purification in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.13
  • LogP   0.4404
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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