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2,6-Diazaspiro[4.5]decane-6-carboxylic acid, 1-oxo-, 1,1-dimethylethyl ester

  • CAS No. 1221818-08-1

  • Cat. No. CS-0028390
  • Molecule weight254.33
  • Purity≥97%
  • MDL No.MFCD15071621

*For research and further manufacturing use only, not for direct human use.

2,6-Diazaspiro[4.5]decane-6-carboxylic acid, 1-oxo-, 1,1-dimethylethyl ester|CS-0028390

Structure of 1221818-08-1

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General Information

  • CAS No. 1221818-08-1
  • Cat. No. CS-0028390
  • Purity ≥97%
  • MDL No. MFCD15071621
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₂N₂O₃
  • Molecular Weight 254.33
  • Synonym(s) 2,6-diazaspiro[4.5]decane-6-carboxylic acid,1-oxo-,1,1-dimethylethyl ester
  • SMILES CC(C)(C)OC(N1C2(CCCC1)C(NCC2)=O)=O

Description

tert-Butyl 1-oxo-2,6-diazaspiro[4.5]decane-6-carboxylate features a rigid spirocyclic core with strategically positioned nitrogen atoms and a carbonyl group, enabling direct incorporation into complex heterocyclic scaffolds. The tert-butyl ester facilitates mild deprotection under acidic conditions, enhancing synthetic versatility in medicinal chemistry workflows.

Application

tert-Butyl 1-oxo-2,6-diazaspiro[4.5]decane-6-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry and synthetic methodology development. Its rigid bicyclic core enables precise spatial control in ligand design, while the ketone and ester functionalities support sequential functionalization via nucleophilic addition, reduction, or coupling reactions. The tert-butyl ester provides bench stability and facile deprotection under mild acidic conditions, enhancing utility in multi-step synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.64
  • LogP   1.6661
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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