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CS-W001157 4
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Methyl 6-fluoro-2-methylnicotinate

  • CAS No. 1227595-02-9

  • Cat. No. CS-0043793
  • Purity≥98%
  • MDL No.MFCD16611614

*For research and further manufacturing use only, not for direct human use.

Methyl 6-fluoro-2-methylnicotinate|CS-0043793

Structure of 1227595-02-9

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General Information

  • CAS No. 1227595-02-9
  • Cat. No. CS-0043793
  • Purity ≥98%
  • MDL No. MFCD16611614
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈FNO₂
  • Molecular Weight 169.15
  • Synonym(s) None
  • SMILES O=C(OC)C1=C(C)N=C(F)C=C1

Description

Methyl 6-fluoro-2-methylnicotinate is a fluorinated pyridine ester featuring a methyl group at the 2-position and a fluoro substituent at the 6-position. This electron-deficient heterocycle integrates readily into synthetic routes for bioactive molecules, offering enhanced metabolic stability and favorable lipophilicity. The ester functionality enables straightforward derivatization under standard conditions.

Application

Methyl 6-fluoro-2-methylnicotinate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its ortho-substituted pyridine core facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions. The methyl ester group offers convenient derivatization potential, while the 6-fluoro and 2-methyl substituents provide defined electronic and steric control, enhancing regioselectivity in downstream transformations.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.31572
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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