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CS-W001157 4
Total: USD 88.00

6-Fluoro-2-methylnicotinic acid

  • CAS No. 884494-97-7

  • Cat. No. CS-W022498
  • Purity≥98%
  • MDL No.MFCD05662400

*For research and further manufacturing use only, not for direct human use.

6-Fluoro-2-methylnicotinic acid|CS-W022498

Structure of 884494-97-7

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General Information

  • CAS No. 884494-97-7
  • Cat. No. CS-W022498
  • Purity ≥98%
  • MDL No. MFCD05662400
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₂
  • Molecular Weight 155.13
  • Synonym(s) 6-fluoro-2-methyl-pyridine-3-carboxylic acid
  • SMILES O=C(C1=CC=C(F)N=C1C)O

Description

6-Fluoro-2-methylnicotinic acid is a fluorinated nicotinic acid derivative featuring a strategically positioned methyl group and fluorine atom. This combination imparts enhanced metabolic stability and modulates electronic properties, making it valuable for medicinal chemistry applications. The molecule integrates readily into bioactive scaffolds, particularly in kinase inhibitors and CNS-targeted therapeutics. Its bench-stable nature supports straightforward handling under standard conditions.

Application

6-Fluoro-2-methylnicotinic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-substituted pyridine framework supports diverse functionalization, while the fluorine and methyl groups enhance metabolic stability and modulate electronic properties. The carboxylic acid functionality facilitates coupling reactions, amide formation, and derivatization under standard conditions. Bench-stable and readily purified by recrystallization, it functions effectively in both small-scale research and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.22732
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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