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CS-W001157 4
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3-Bromo-2-fluorophenylacetic acid

  • CAS No. 1375964-39-8

  • Cat. No. CS-0041781
  • Purity≥97%
  • MDL No.MFCD09864663

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-fluorophenylacetic acid|CS-0041781

Structure of 1375964-39-8

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General Information

  • CAS No. 1375964-39-8
  • Cat. No. CS-0041781
  • Purity ≥97%
  • MDL No. MFCD09864663
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrFO₂
  • Molecular Weight 233.04
  • Synonym(s) (3-Bromo-2-fluorophenyl)acetic acid
  • SMILES BrC1=CC=CC(=C1F)CC(=O)O

Description

3-Bromo-2-fluorophenylacetic acid features a bromo and fluoro substituent positioned ortho to the acetic acid side chain on a phenyl ring, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables direct incorporation into pharmaceutical intermediates requiring halogenated aromatic platforms, particularly in kinase inhibitor scaffolds and bioactive heterocycles. The molecule exhibits excellent solubility in common organic solvents and maintains stability under standard bench conditions.

Application

3-Bromo-2-fluorophenylacetic acid serves as a valuable building block for pharmaceutical and agrochemical synthesis, enabling efficient access to substituted benzene derivatives via standard coupling reactions. Its orthogonal halogenation pattern facilitates selective functionalization, while the carboxylic acid group supports direct derivatization or activation. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthetic sequences in medicinal chemistry.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.2153
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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