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CS-W001157 4
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2-Chloro-4-iodo-6-methylpyridine

  • CAS No. 1227592-89-3

  • Cat. No. CS-0161372
  • Purity≥98%
  • MDL No.MFCD16610530

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-iodo-6-methylpyridine|CS-0161372

Structure of 1227592-89-3

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General Information

  • CAS No. 1227592-89-3
  • Cat. No. CS-0161372
  • Purity ≥98%
  • MDL No. MFCD16610530
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClIN
  • Molecular Weight 253.47
  • Synonym(s) 2-Chloro-4-iodo-6-methyl-pyridine
  • SMILES CC1=CC(I)=CC(Cl)=N1

Description

2-Chloro-4-iodo-6-methylpyridine features a trifunctional pyridine core with complementary halogen handles, enabling sequential cross-coupling reactions. The chlorine and iodine substituents facilitate orthogonal reactivity in palladium-catalyzed transformations, while the methyl group enhances solubility and electronic modulation. This bench-stable derivative serves as a key building block for bioactive heterocycles and advanced pharmaceutical intermediates.

Application

2-Chloro-4-iodo-6-methylpyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki, Stille, and Negishi reactions due to its orthogonal halogen reactivity. The chloro group exhibits high stability under standard reaction conditions, while the iodo substituent facilitates rapid coupling with boronic acids and organometallics. Its methyl group provides a convenient handle for further functionalization, and the molecule demonstrates excellent bench stability and ease of purification—ideal for iterative synthesis of complex heterocyclic scaffolds and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.64802
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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