1-Bromo-4-fluoro-2-methyl-3-nitrobenzene

Name: 1-Bromo-4-fluoro-2-methyl-3-nitrobenzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1227210-35-6
Cat. No. CS-0138316
Purity≥98%
MDL No.MFCD20486202

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Bromo-4-fluoro-2-methyl-3-nitrobenzene|CS-0138316

Structure of 1227210-35-6

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1227210-35-6
Cat. No. CS-0138316
Purity ≥98%
MDL No. MFCD20486202
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅BrFNO₂
Molecular Weight 234.02
Synonym(s) 1-bromo-4-fluoro-2-methyl-3-nitro-benzene
SMILES O=[N+](C1=C(C)C(Br)=CC=C1F)[O-]

Description

1-Bromo-4-fluoro-2-methyl-3-nitrobenzene features a densely functionalized aromatic core with orthogonal reactivity. The bromine enables palladium-catalyzed cross-coupling, while the fluorine supports nucleophilic substitution under mild conditions. The para-fluoro and ortho-methyl groups modulate electronic distribution and steric accessibility, enhancing selectivity in complex synthesis. This compound serves as a key intermediate for pharmaceuticals and advanced materials.

Application

1-Bromo-4-fluoro-2-methyl-3-nitrobenzene serves as a versatile building block for the synthesis of functionalized aromatic scaffolds. The molecule enables palladium-catalyzed cross-coupling reactions due to its bromo substituent, while the fluoro and nitro groups offer orthogonal reactivity for sequential transformations. Its bench-stable nature and compatibility with standard synthetic protocols make it suitable for medicinal chemistry and process development workflows requiring precise regiocontrol.

Synthesis

Route1
- In-stock
  
  3013-27-2
- ~79%
- In-stock
  
  1227210-35-6
References
- CGI PHARMACEUTICALS, INC.; GENENTECH, INC.; BARBOSA, Antonio, J., Jr.; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; LEE, Seung, H.; KROPF, Jeffrey, E.; MITCHELL, Scott, A.; ORTWINE, Daniel; RENNELLS, William, M.; SCHMITT, Aaron, C.; XU, Jianjun; YOUNG, Wendy, B.; ZHAO, Zhongdong; ZHICHKIN, Pavel, E. Patent: WO2010/56875 A1, 2010 ; Location in patent: Page/Page column 102 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 43.14
LogP 2.80482
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

1-Bromo-4-fluoro-2-methyl-3-nitrobenzene sigma1-Bromo-4-fluoro-2-methyl-3-nitrobenzene manufacturer1-Bromo-4-fluoro-2-methyl-3-nitrobenzene price1-Bromo-4-fluoro-2-methyl-3-nitrobenzene structure1-Bromo-4-fluoro-2-methyl-3-nitrobenzene SDSbuy 1-Bromo-4-fluoro-2-methyl-3-nitrobenzene1-Bromo-4-fluoro-2-methyl-3-nitrobenzene supplier1-Bromo-4-fluoro-2-methyl-3-nitrobenzene uses1-Bromo-4-fluoro-2-methyl-3-nitrobenzene molecular weightprice of 1-Bromo-4-fluoro-2-methyl-3-nitrobenzene1-Bromo-4-fluoro-2-methyl-3-nitrobenzene chemical name formula of 1-Bromo-4-fluoro-2-methyl-3-nitrobenzene

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1-Bromo-4-fluoro-2-methyl-3-nitrobenzene

CAS No. 1227210-35-6

Recommended Products