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CS-W001157 4
Total: USD 88.00

2-Fluoro-5-methoxyphenol

  • CAS No. 117902-16-6

  • Cat. No. CS-0133711
  • Purity≥98%
  • MDL No.MFCD16998752

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-methoxyphenol|CS-0133711

Structure of 117902-16-6

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General Information

  • CAS No. 117902-16-6
  • Cat. No. CS-0133711
  • Purity ≥98%
  • MDL No. MFCD16998752
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO₂
  • Molecular Weight 142.13
  • Synonym(s) None
  • SMILES OC1=CC(OC)=CC=C1F

Description

2-Fluoro-5-methoxyphenol features a fluorine atom at the ortho position and a methoxy group at the para position relative to the phenolic hydroxyl, creating a uniquely activated aromatic system. This combination imparts enhanced reactivity in electrophilic substitution reactions while maintaining stability under standard bench conditions. The molecule integrates readily into complex synthetic sequences requiring electron-deficient aryl motifs with polar functional handles.

Application

2-Fluoro-5-methoxyphenol serves as a valuable building block in medicinal chemistry, enabling direct introduction of both fluorine and methoxy functionalities into aromatic scaffolds. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of substituted aryl intermediates for pharmaceutical development.

Synthesis

  • Route1

    References

    • Eisai RandD Management Co., Ltd.; CLARK, Richard; MATSUURA, Fumiyoshi; SHINODA, Masanobu; HIROTA, Shinsuke; KIRA, Kazunobu; AZUMA, Hiroshi; TAKEMURA, Atsushi; YASUI, So; KUSANO, Kazutomi; MIKAMOTO, Masaki; OMAE, Takao Patent: WO2011/145747 A1, 2011 ; Location in patent: Page/Page column 97-98 ; WO 2011/145747 A1
  • Route2

    References

    • Belanger, Patrice C.; Lau, C. K.; Williams, Haydn W. R.; Dufresne, C.; Scheigetz, John Canadian Journal of Chemistry, 1988 , vol. 66, p. 1479 - 1482
  • Route3

    References

    • Belanger, Patrice C.; Lau, C. K.; Williams, Haydn W. R.; Dufresne, C.; Scheigetz, John Canadian Journal of Chemistry, 1988 , vol. 66, p. 1479 - 1482

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.5399
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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