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CS-W001157 4
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4-Fluoro-3-methoxyphenol

  • CAS No. 117902-15-5

  • Cat. No. CS-W022178
  • Purity≥97%
  • MDL No.MFCD10698649

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-methoxyphenol|CS-W022178

Structure of 117902-15-5

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General Information

  • CAS No. 117902-15-5
  • Cat. No. CS-W022178
  • Purity ≥97%
  • MDL No. MFCD10698649
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO₂
  • Molecular Weight 142.13
  • Synonym(s) 4-hydroxy-2-methoxy-fluorobenzene
  • SMILES OC1=CC=C(F)C(OC)=C1

Description

4-Fluoro-3-methoxyphenol features a fluorine atom at the para position relative to the hydroxyl group and a methoxy substituent at the meta position, creating a uniquely polarized aromatic system. This combination imparts enhanced solubility in organic solvents while maintaining stability under standard bench conditions. The molecule serves as a key intermediate in the synthesis of bioactive heterocycles and functionalized polymers.

Application

4-Fluoro-3-methoxyphenol serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds with enhanced metabolic stability. Its ortho-hydroxy and methoxy substituents provide complementary reactivity for selective derivatization, while the fluorine atom imparts favorable electronic and lipophilic properties. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development.

Synthesis

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      4-Fluoro-3-methoxyphenol|CS-W022178
      117902-15-5

    References

    • WO2012/27134 A1, ; Page/Page column 2; 3; 4 ;
  • Route2

    References

    • AUTIFONY THERAPEUTICS LIMITED; MARASCO, Agostino; ALVARO, Giuseppe; DECOR, Anne; HAMPRECHT, Dieter; DAMBRUOSO, Paolo; TOMMASI, Simona Patent: WO2013/175215 A1, 2013 ; Location in patent: Page/Page column 70 ; 71 ;
  • Route3

    References

    • WO2012/27134 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.5399
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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