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CS-W001157 4
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1-(Azetidin-3-yl)-1H-pyrazole dihydrochloride

  • CAS No. 1221715-95-2

  • Cat. No. CS-0155609
  • Molecule weight196.08
  • Purity≥97%
  • MDL No.MFCD09864482

*For research and further manufacturing use only, not for direct human use.

1-(Azetidin-3-yl)-1H-pyrazole dihydrochloride|CS-0155609

Structure of 1221715-95-2

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General Information

  • CAS No. 1221715-95-2
  • Cat. No. CS-0155609
  • Purity ≥97%
  • MDL No. MFCD09864482
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁Cl₂N₃
  • Molecular Weight 196.08
  • Synonym(s) 1-(Azetidin-3-yl)-1H-pyrazole hydrochloride
  • SMILES C1=CN(C2CNC2)N=C1.Cl.Cl

Description

This dihydrochloride salt features a pyrazole core linked to an azetidinyl group, delivering enhanced solubility and stability under standard conditions. The protonated azetidine moiety improves cellular permeability, while the rigid heterocyclic framework supports targeted interactions in medicinal chemistry applications.

Application

1-(Azetidin-3-yl)-1H-pyrazole dihydrochloride serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. The azetidine moiety provides enhanced metabolic stability and improved membrane permeability, while the pyrazole core offers robust hydrogen-bonding capacity and structural rigidity. This compound facilitates direct incorporation into drug-like molecules via standard coupling reactions, with excellent bench stability and ease of purification due to its crystalline dihydrochloride salt form.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   29.85
  • LogP   0.871
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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