(R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride

Name: (R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 1218935-60-4
Cat. No. CS-M3733
Purity≥97%
MDL No.MFCD08751413

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride|CS-M3733

Structure of 1218935-60-4

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General Information

CAS No. 1218935-60-4
Cat. No. CS-M3733
Purity ≥97%
MDL No. MFCD08751413
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₂ClF₂N
Molecular Weight 219.66
Synonym(s) (R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE HCL
SMILES FC1=CC=C(F)C=C1[C@@H]2NCCC2.Cl

Description

(R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride is a chiral building block featuring a fluorinated aromatic ring and a stereodefined pyrrolidine core. This bench-stable salt delivers enhanced solubility and handling convenience in synthetic workflows. The para-fluorine substitution imparts favorable electronic and metabolic stability, while the (R)-configuration ensures precise stereocontrol in asymmetric synthesis. It integrates readily into pharmaceutical intermediates and functional materials.

Application

(R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of bioactive molecules through established coupling and functionalization reactions. Its bench-stable hydrochloride salt form facilitates handling and purification, while the (R)-configured pyrrolidine core provides stereochemical control in target-directed synthesis. The 2,5-difluorophenyl moiety enhances metabolic stability and modulates electronic properties, making this scaffold particularly useful in developing CNS-targeted therapeutics and kinase inhibitors.

Synthesis

Route1
- 1218935-58-0
- ~%
- In-stock
  
  1218935-60-4
References
- ARRAY BIOPHARMA INC.; ANDREWS, Steven, W.; HAAS, Julia; JIANG, Yutong; ZHANG, Gan Patent: WO2010/33941 A1, 2010 ; Location in patent: Page/Page column 34 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 12.03
LogP 2.8111
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride

CAS No. 1218935-60-4

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