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Structure of 252742-72-6
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3-(Chloromethyl)-1H-1,2,4-triazol-5(4H)-one features a reactive chloromethyl group attached to a triazolone scaffold, enabling efficient alkylation under mild conditions. This electrophilic handle facilitates conjugation with nucleophiles such as amines and thiols, making it valuable for bioconjugation and the synthesis of functionalized heterocycles in medicinal chemistry and chemical biology applications.
3-(Chloromethyl)-1H-1,2,4-triazol-5(4H)-one serves as a versatile building block for the synthesis of triazolyl-containing heterocycles and bioactive molecules. The chloromethyl group enables efficient alkylation and nucleophilic substitution reactions, facilitating the construction of pharmaceutical scaffolds. Its stability under standard bench conditions and compatibility with common protecting group strategies make it a practical choice for iterative synthetic sequences in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: