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CS-W001157 4
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1-(2,4-Dimethoxyphenyl)-N-methylmethanamine

  • CAS No. 102503-23-1

  • Cat. No. CS-W006302
  • Purity≥95%
  • MDL No.MFCD04633426

*For research and further manufacturing use only, not for direct human use.

1-(2,4-Dimethoxyphenyl)-N-methylmethanamine|CS-W006302

Structure of 102503-23-1

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General Information

  • CAS No. 102503-23-1
  • Cat. No. CS-W006302
  • Purity ≥95%
  • MDL No. MFCD04633426
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅NO₂
  • Molecular Weight 181.23
  • Synonym(s) N-Methyl-2,4-Dimethoxybenzylamine
  • SMILES CNCC1=C(OC)C=C(OC)C=C1

Description

This N-methylated arylamine features a 2,4-dimethoxyphenyl scaffold that enhances solubility and modulates electronic properties. The methoxy groups stabilize electron density across the aromatic ring, while the methylamino functionality provides a reactive handle for downstream conjugation. Ideal for medicinal chemistry campaigns requiring tunable lipophilicity and metabolic resistance.

Application

1-(2,4-Dimethoxyphenyl)-N-methylmethanamine serves as a versatile building block for medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted aniline derivatives. Its ortho- and para-dimethoxy substitution pattern enhances solubility and provides stable, bench-ready reactivity in coupling and functionalization reactions. The N-methylated amine functionality facilitates direct incorporation into bioactive scaffolds and supports broad compatibility with standard synthetic protocols.

Synthesis

  • Route1
    • In-stock
      2,4-Dimethoxybenzaldehyde|CS-W020102
      613-45-6
    • null|null
      74-89-5
    • ~83%
    • In-stock
      1-(2,4-Dimethoxyphenyl)-N-methylmethanamine|CS-W006302
      102503-23-1

    References

    • TAKEDA PHARMACEUTICAL COMPANY LIMITED Patent: WO2008/108380 A2, 2008 ; Location in patent: Page/Page column 103-104 ;
  • Route2
    • null|null
      84572-02-1
    • ~%
    • In-stock
      1-(2,4-Dimethoxyphenyl)-N-methylmethanamine|CS-W006302
      102503-23-1

    References

    • US2009/23740 A1, ; Page/Page column 44 ;
  • Route3

    References

    • Organic and Biomolecular Chemistry, , vol. 10, # 37 p. 7610 - 7617

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.49
  • LogP   1.4232
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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