Lot numbers can be found on the outside label of a product:
(R)-2-(2,5-Difluorophenyl)pyrrolidine
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CAS No. 1218935-59-1
- Cat. No. CS-0055107
- Purity≥97%
- MDL No.MFCD07772701
*For research and further manufacturing use only, not for direct human use.
Structure of 1218935-59-1
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General Information
- CAS No. 1218935-59-1
- Cat. No. CS-0055107
- Purity ≥97%
- MDL No. MFCD07772701
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₁F₂N
- Molecular Weight 183.20
- Synonym(s) Larotrectinib Impurity 7
- SMILES FC1=CC=C(F)C([C@@H]2NCCC2)=C1
Description
(R)-2-(2,5-Difluorophenyl)pyrrolidine is a chiral building block featuring a sterically defined pyrrolidine ring fused to a 2,5-difluorophenyl group. This configuration imparts enhanced conformational rigidity and favorable binding interactions in medicinal chemistry applications. The molecule exhibits bench-stable handling characteristics and integrates efficiently into complex molecular architectures.
Application
(R)-2-(2,5-Difluorophenyl)pyrrolidine serves as a key chiral building block in medicinal chemistry, enabling the construction of bioactive scaffolds with defined stereochemistry. Its pyrrolidine core exhibits favorable solubility and metabolic stability, while the ortho-difluorophenyl group enhances target binding affinity through polar interactions and modulates lipophilicity. The compound demonstrates robust bench stability and compatibility with standard coupling reactions, facilitating efficient synthesis of complex heterocyclic structures in drug discovery workflows.
Synthesis
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Route1
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In-stock
399-94-0 - ~%
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In-stock
1218935-59-1
References
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ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven S.; CONDROSKI, Kevin Ronald; HAAS, Julia; HUANG, Lily; JIANG, Yutong; KERCHER, Timothy; SEO, Jeongbeob Patent: WO2011/6074 A1, 2011 ;
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Route2
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1218935-58-0 - ~%
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In-stock
1218935-59-1
References
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ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven S.; CONDROSKI, Kevin Ronald; HAAS, Julia; HUANG, Lily; JIANG, Yutong; KERCHER, Timothy; SEO, Jeongbeob Patent: WO2011/6074 A1, 2011 ;
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Route3
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In-stock
1218935-60-4 - ~%
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In-stock
1218935-59-1
References
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ARRAY BIOPHARMA INC.; ANDREWS, Steven, W.; HAAS, Julia; JIANG, Yutong; ZHANG, Gan Patent: WO2010/33941 A1, 2010 ; Location in patent: Page/Page column 34 ; WO 2010/033941 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 12.03
- LogP 2.3893
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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