(R)-2-(2,5-Difluorophenyl)pyrrolidine

Name: (R)-2-(2,5-Difluorophenyl)pyrrolidine
Brand: ChemScene
Availability: InStock
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CAS No. 1218935-59-1
Cat. No. CS-0055107
Purity≥97%
MDL No.MFCD07772701

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-2-(2,5-Difluorophenyl)pyrrolidine|CS-0055107

Structure of 1218935-59-1

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Description

(R)-2-(2,5-Difluorophenyl)pyrrolidine is a chiral building block featuring a sterically defined pyrrolidine ring fused to a 2,5-difluorophenyl group. This configuration imparts enhanced conformational rigidity and favorable binding interactions in medicinal chemistry applications. The molecule exhibits bench-stable handling characteristics and integrates efficiently into complex molecular architectures.

Application

(R)-2-(2,5-Difluorophenyl)pyrrolidine serves as a key chiral building block in medicinal chemistry, enabling the construction of bioactive scaffolds with defined stereochemistry. Its pyrrolidine core exhibits favorable solubility and metabolic stability, while the ortho-difluorophenyl group enhances target binding affinity through polar interactions and modulates lipophilicity. The compound demonstrates robust bench stability and compatibility with standard coupling reactions, facilitating efficient synthesis of complex heterocyclic structures in drug discovery workflows.

General Information

CAS No. 1218935-59-1
Cat. No. CS-0055107
Purity ≥97%
MDL No. MFCD07772701
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₁F₂N
Molecular Weight 183.20
Synonym(s) Larotrectinib Impurity 7
SMILES FC1=CC=C(F)C([C@@H]2NCCC2)=C1

Computational Chemistry Data

TPSA 12.03
LogP 2.3893
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-2-(2,5-Difluorophenyl)pyrrolidine

CAS No. 1218935-59-1

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