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1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride

  • CAS No. 1215071-12-7

  • Cat. No. CS-0052765
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride|CS-0052765

Structure of 1215071-12-7

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General Information

  • CAS No. 1215071-12-7
  • Cat. No. CS-0052765
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀ClF₂N
  • Molecular Weight 169.60
  • Synonym(s) 2,2-difluoro-5-azaspiro[2.4]heptane
  • SMILES Cl.FC1(F)CC11CCNC1

Description

This difluorinated spirocyclic amine features a rigid, electron-deficient core ideal for probing conformational preferences in medicinal chemistry. The hydrochloride salt enhances solubility and stability, enabling straightforward incorporation into synthetic routes targeting CNS-active compounds and fluorinated heterocycles.

Application

1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride serves as a rigid, conformationally constrained building block for medicinal chemistry campaigns, enabling the introduction of fluorinated spirocyclic motifs with enhanced metabolic stability. The difluoromethylene group imparts strong electron-withdrawing character and improves membrane permeability, while the protonated amine enhances solubility and facilitates salt formation. Its robust bench stability and compatibility with standard coupling reactions make it ideal for rapid library synthesis and structure–activity relationship studies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.4269
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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