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CS-W001157 4
Total: USD 88.00

5-Bromo-6-methoxypicolinic acid

  • CAS No. 1214334-70-9

  • Cat. No. CS-W022332
  • Molecule weight232.03
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-6-methoxypicolinic acid|CS-W022332

Structure of 1214334-70-9

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General Information

  • CAS No. 1214334-70-9
  • Cat. No. CS-W022332
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₃
  • Molecular Weight 232.03
  • Synonym(s) 5-Bromo-6-methoxypyridine-2-carboxylic acid
  • SMILES O=C(O)C1=NC(OC)=C(Br)C=C1

Description

5-Bromo-6-methoxypicolinic acid features a bromine substituent at the 5-position and a methoxy group at the 6-position of the picolinic acid scaffold, delivering enhanced electronic modulation and solubility. This combination enables efficient incorporation into bioactive heterocycles and facilitates downstream functionalization in medicinal chemistry campaigns.

Application

5-Bromo-6-methoxypicolinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its bromo group enables palladium-catalyzed cross-coupling reactions, while the methoxy and carboxylic acid functionalities offer orthogonal reactivity for derivatization. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • WO2011/48525 A1, ; WO 2011/048525 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.5509
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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