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CS-W001157 4
Total: USD 88.00

3-Chloro-5-fluoropyridin-2-amine

  • CAS No. 1214330-79-6

  • Cat. No. CS-W021903
  • Molecule weight146.55
  • Purity≥98%
  • MDL No.MFCD09260907

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-fluoropyridin-2-amine|CS-W021903

Structure of 1214330-79-6

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General Information

  • CAS No. 1214330-79-6
  • Cat. No. CS-W021903
  • Purity ≥98%
  • MDL No. MFCD09260907
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClFN₂
  • Molecular Weight 146.55
  • Synonym(s) 2-AMINO-3-CHLORO-5-FLUOROPYRIDINE
  • SMILES NC1=NC=C(F)C=C1Cl

Description

3-Chloro-5-fluoropyridin-2-amine features a trifluorinated pyridine core with orthogonal halogen substituents enabling selective cross-coupling. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, offering enhanced metabolic stability and improved solubility in polar reaction media.

Application

3-Chloro-5-fluoropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. Its orthogonal halogen reactivity supports palladium-catalyzed cross-coupling reactions, while the primary amine facilitates derivatization via acylation or alkylation. Bench-stable and readily purified, it functions effectively in standard synthetic workflows for API development and heterocyclic library construction.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.4563
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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