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(S)-1-(3,4-Difluorophenyl)ethanamine hydrochloride

  • CAS No. 1212972-48-9

  • Cat. No. CS-0158268
  • Purity≥97%
  • MDL No.MFCD11101246

*For research and further manufacturing use only, not for direct human use.

(S)-1-(3,4-Difluorophenyl)ethanamine hydrochloride|CS-0158268

Structure of 1212972-48-9

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General Information

  • CAS No. 1212972-48-9
  • Cat. No. CS-0158268
  • Purity ≥97%
  • MDL No. MFCD11101246
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀ClF₂N
  • Molecular Weight 193.62
  • Synonym(s) (S)-1-(3,4-Difluorophenyl)ethylamine hydrochloride
  • SMILES C[C@@H](C1=CC(=C(C=C1)F)F)N.Cl

Description

(S)-1-(3,4-Difluorophenyl)ethanamine hydrochloride is a chiral building block featuring a sterically defined amine center flanked by a 3,4-difluorophenyl group. This bench-stable salt delivers high enantiomeric purity and facilitates direct incorporation into pharmaceutical intermediates, enabling efficient access to bioactive molecules through asymmetric synthesis.

Application

(S)-1-(3,4-Difluorophenyl)ethanamine hydrochloride serves as a chiral building block for pharmaceutical intermediates, enabling efficient access to bioactive scaffolds via standard amine functionalization. Its bench-stable salt form facilitates handling and purification, while the ortho-difluoro substitution enhances metabolic stability and modulates electronic properties in target molecules. Functions reliably in reductive amination, coupling reactions, and asymmetric synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.4063
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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