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(R)-3,3,3-Trifluoro-2-hydroxypropanoic acid

  • CAS No. 121250-04-2

  • Cat. No. CS-0135746
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-3,3,3-Trifluoro-2-hydroxypropanoic acid|CS-0135746

Structure of 121250-04-2

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General Information

  • CAS No. 121250-04-2
  • Cat. No. CS-0135746
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₃F₃O₃
  • Molecular Weight 144.05
  • Synonym(s) (R)-3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID
  • SMILES O=C(O)[C@@H](O)C(F)(F)F

Description

(R)-3,3,3-Trifluoro-2-hydroxypropanoic acid features a chiral center flanked by a trifluoromethyl group and a hydroxyl-bearing carbon, delivering high polarity and enhanced metabolic stability. This configuration enables precise stereochemical control in asymmetric synthesis, particularly as a building block for fluorinated bioactive molecules and enzyme inhibitors.

Application

(R)-3,3,3-Trifluoro-2-hydroxypropanoic acid serves as a valuable chiral building block for fluorinated β-hydroxy carboxylic acid scaffolds. Its well-defined stereochemistry and trifluoromethyl group enable predictable reactivity in esterification, amidation, and coupling reactions. The molecule exhibits bench stability and facilitates access to fluorinated intermediates relevant to medicinal chemistry and agrochemical synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.0058
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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