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CS-W001157 4
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3-Bromo-6-fluoropicolinic acid

  • CAS No. 1211589-43-3

  • Cat. No. CS-0042050
  • Purity≥95%
  • MDL No.MFCD13185802

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-fluoropicolinic acid|CS-0042050

Structure of 1211589-43-3

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General Information

  • CAS No. 1211589-43-3
  • Cat. No. CS-0042050
  • Purity ≥95%
  • MDL No. MFCD13185802
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrFNO₂
  • Molecular Weight 220.00
  • Synonym(s) 3-Bromo-6-fluoropyridine-2-carboxylicacid
  • SMILES O=C(O)C1=NC(F)=CC=C1Br

Description

3-Bromo-6-fluoropicolinic acid features a strategically positioned bromo and fluoro substituent on the picolinic acid scaffold, enabling selective functionalization in cross-coupling reactions. This electron-deficient heterocycle delivers high reactivity under palladium catalysis while maintaining bench-stable handling characteristics.

Application

3-Bromo-6-fluoropicolinic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 3-position via palladium-catalyzed cross-coupling reactions. Its orthogonal halogenation pattern (Br and F) supports sequential transformations and facilitates late-stage diversification in API synthesis. The carboxylic acid group provides a handle for amide formation or ester derivatization, while the molecule exhibits excellent bench stability and compatibility with standard purification methods.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.6814
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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