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Structure of 1211587-46-0
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2-(Difluoromethoxy)pyridin-4-amine features a difluoromethoxy group at the 2-position and an amino substituent at the 4-position of the pyridine ring, creating a unique electronic profile. This configuration enhances solubility and stability while enabling selective coupling in medicinal chemistry applications.
2-(Difluoromethoxy)pyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its difluoromethoxy group imparts enhanced metabolic stability and modulated lipophilicity, while the pyridin-4-amine functionality facilitates facile derivatization via Suzuki-Miyaura, Buchwald-Hartwig, or reductive amination protocols. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis campaigns in drug discovery.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: