tert-Butyl 4-amino-4-(trifluoromethyl)piperidine-1-carboxylate

Name: tert-Butyl 4-amino-4-(trifluoromethyl)piperidine-1-carboxylate
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CAS No. 1211582-61-4
Cat. No. CS-0048227
Molecule weight268.28
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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tert-Butyl 4-amino-4-(trifluoromethyl)piperidine-1-carboxylate|CS-0048227

Structure of 1211582-61-4

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General Information

CAS No. 1211582-61-4
Cat. No. CS-0048227
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₉F₃N₂O₂
Molecular Weight 268.28
Synonym(s) 1-Piperidinecarboxylic acid, 4-amino-4-(trifluoromethyl)-, 1,1-dimethylethyl ester
SMILES CC(C)(C)OC(=O)N1CCC(N)(CC1)C(F)(F)F

Description

tert-Butyl 4-amino-4-(trifluoromethyl)piperidine-1-carboxylate features a sterically hindered piperidine core bearing a trifluoromethyl group and a protected amine, offering enhanced stability and solubility in organic synthesis. This building block facilitates efficient access to bioactive scaffolds in medicinal chemistry.

Application

tert-Butyl 4-amino-4-(trifluoromethyl)piperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to trifluoromethylated piperidine scaffolds. The tert-butyl carbamate group provides excellent stability and ease of removal under mild acidic conditions, while the primary amine facilitates diverse functionalization. Its compatibility with standard coupling reactions and tolerance to common protecting groups supports streamlined synthesis of bioactive molecules.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 55.56
LogP 2.2771
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl 4-amino-4-(trifluoromethyl)piperidine-1-carboxylate

CAS No. 1211582-61-4

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