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CS-W001157 4
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5-Bromobenzofuran-2-carboxylic acid

  • CAS No. 10242-11-2

  • Cat. No. CS-0062572
  • Purity≥96%
  • MDL No.MFCD00093973

*For research and further manufacturing use only, not for direct human use.

5-Bromobenzofuran-2-carboxylic acid|CS-0062572

Structure of 10242-11-2

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General Information

  • CAS No. 10242-11-2
  • Cat. No. CS-0062572
  • Purity ≥96%
  • MDL No. MFCD00093973
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅BrO₃
  • Molecular Weight 241.04
  • Synonym(s) BUTTPARK 34\07-74
  • SMILES O=C(C1=CC2=CC(Br)=CC=C2O1)O

Description

This boronate moiety integrates seamlessly into Suzuki-Miyaura cross-coupling reactions, offering high functional group tolerance and stability under standard conditions. The electron-deficient aromatic core enables efficient derivatization, while the carboxylic acid handle facilitates direct conjugation or activation for peptide synthesis and bioconjugation workflows.

Application

5-Bromobenzofuran-2-carboxylic acid serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid group facilitates derivatization via amide formation or esterification. The molecule exhibits good bench stability and is compatible with standard synthetic workflows, making it a practical choice for medicinal chemistry campaigns targeting fused aromatic systems.

Synthesis

  • Route1
    • null|null
      125418-95-3
    • ~10%
    • In-stock
      5-Bromobenzofuran-2-carboxylic acid|CS-0062572
      10242-11-2

    References

    • US5990142 A1, ;
  • Route2

    References

    • US2005/192288 A1, ; Page/Page column 6 ;
  • Route3

    References

    • Antimicrobial Agents and Chemotherapy, , vol. 42, # 10 p. 2495 - 2502

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.44
  • LogP   2.8935
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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