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CS-W001157 4
Total: USD 88.00

3-Bromo-2-chloro-6-fluoropyridine

  • CAS No. 1211578-75-4

  • Cat. No. CS-0442307
  • Purity≥98%
  • MDL No.MFCD18257575

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-chloro-6-fluoropyridine|CS-0442307

Structure of 1211578-75-4

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General Information

  • CAS No. 1211578-75-4
  • Cat. No. CS-0442307
  • Purity ≥98%
  • MDL No. MFCD18257575
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrClFN
  • Molecular Weight 210.43
  • Synonym(s) None
  • SMILES C1=CC(=NC(=C1Br)Cl)F

Description

3-Bromo-2-chloro-6-fluoropyridine is a halogenated pyridine derivative featuring strategically positioned bromo, chloro, and fluoro substituents. This combination enables selective cross-coupling reactions in medicinal chemistry and agrochemical synthesis. The molecule exhibits enhanced reactivity due to the electron-withdrawing nature of its substituents, facilitating palladium-catalyzed transformations under mild conditions.

Application

3-Bromo-2-chloro-6-fluoropyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its strategically positioned halogens (Br, Cl, F) exhibit orthogonal reactivity, facilitating sequential derivatization with high chemoselectivity. The compound demonstrates excellent bench stability and compatibility with standard reaction conditions, making it ideal for constructing complex pyridine-based scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P264-P270-P330

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.6366
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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