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Structure of 1211535-84-0
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4-Fluoro-5-methylpyridin-2-amine features a strategically positioned fluorine atom and methyl group on the pyridine ring, delivering enhanced electronic modulation and metabolic stability. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, serving as a key building block for kinase inhibitors and bioactive small molecules in medicinal chemistry.
4-Fluoro-5-methylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through cross-coupling and nucleophilic substitution reactions. The ortho-fluoro group facilitates palladium-catalyzed coupling with arylboranes and amines, while the 5-methyl substituent enhances metabolic stability and modulates electronic properties. Its bench-stable solid form simplifies handling and purification, supporting scalable synthesis of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: