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CS-W001157 4
Total: USD 88.00

4-Bromo-3-methylpicolinic acid

  • CAS No. 1211526-84-9

  • Cat. No. CS-0135286
  • Purity≥95%
  • MDL No.MFCD18257506
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3-methylpicolinic acid|CS-0135286

Structure of 1211526-84-9

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Description

4-Bromo-3-methylpicolinic acid is a bench-stable, electron-deficient heteroaromatic building block featuring a bromine at the 4-position and a methyl group at the 3-position on the picolinic acid scaffold. This combination enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive molecules requiring tailored electronic and steric profiles.

Application

4-Bromo-3-methylpicolinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via palladium-catalyzed cross-coupling reactions. Its ortho-brominated pyridine core exhibits excellent functional group tolerance and bench stability, facilitating direct derivatization in Suzuki-Miyaura and Buchwald-Hartwig transformations. The methyl group provides a handle for further alkylation or oxidation, while the carboxylic acid functionality supports amide formation and conjugation strategies in API development.

General Information

  • CAS No. 1211526-84-9
  • Cat. No. CS-0135286
  • Purity ≥95%
  • MDL No. MFCD18257506
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₂
  • Molecular Weight 216.03
  • Synonym(s) 4-bromo-3-methyl-pyridine-2-carboxylic acid
  • SMILES O=C(O)C1=NC=CC(Br)=C1C

Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.85072
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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