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Structure of 1211526-84-9
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4-Bromo-3-methylpicolinic acid is a bench-stable, electron-deficient heteroaromatic building block featuring a bromine at the 4-position and a methyl group at the 3-position on the picolinic acid scaffold. This combination enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive molecules requiring tailored electronic and steric profiles.
4-Bromo-3-methylpicolinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via palladium-catalyzed cross-coupling reactions. Its ortho-brominated pyridine core exhibits excellent functional group tolerance and bench stability, facilitating direct derivatization in Suzuki-Miyaura and Buchwald-Hartwig transformations. The methyl group provides a handle for further alkylation or oxidation, while the carboxylic acid functionality supports amide formation and conjugation strategies in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: