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Structure of 1204580-94-8
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This boronic acid features a trifluoromethyl group at the 5-position and a formyl substituent at the 2-position, creating a uniquely electron-deficient arylboronate. The orthogonal functional groups enable direct coupling in Suzuki-Miyaura reactions followed by selective transformations, streamlining access to complex heterocycles and bioactive scaffolds under standard conditions.
(2-Formyl-5-(trifluoromethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The ortho-formyl group provides a handle for downstream functionalization via condensation or oxidation, while the trifluoromethyl substituent enhances metabolic stability and lipophilicity—key attributes in medicinal chemistry. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses of complex heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: