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6-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine

  • CAS No. 1203499-17-5

  • Cat. No. CS-0100022
  • Purity≥98%
  • MDL No.MFCD13563085

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine|CS-0100022

Structure of 1203499-17-5

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General Information

  • CAS No. 1203499-17-5
  • Cat. No. CS-0100022
  • Purity ≥98%
  • MDL No. MFCD13563085
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrN₂O
  • Molecular Weight 215.05
  • Synonym(s) None
  • SMILES BrC1=CC=C2C(OCCN2)=N1

Description

6-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine is a brominated heterocyclic scaffold featuring a fused pyridine-oxazine core. This bench-stable compound integrates a reactive bromo handle at the C6 position, enabling straightforward functionalization via cross-coupling reactions. The electron-deficient nature of the oxazine ring enhances its utility in transition-metal-catalyzed transformations.

Application

6-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C6 position via palladium-catalyzed cross-coupling reactions. Its dihydrooxazine core offers enhanced bench stability and compatibility with diverse reaction conditions, facilitating efficient access to substituted pyridine scaffolds. The bromine substituent provides a reliable handle for further derivatization, making this compound well-suited for iterative synthesis of complex heterocyclic architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   34.15
  • LogP   1.6484
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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