7-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine

Name: 7-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 946121-78-4
Cat. No. CS-0128559
Purity≥96%
MDL No.MFCD15527041

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7-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine|CS-0128559

Structure of 946121-78-4

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General Information

CAS No. 946121-78-4
Cat. No. CS-0128559
Purity ≥96%
MDL No. MFCD15527041
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇BrN₂O
Molecular Weight 215.05
Synonym(s) 7-bromo-1H,2H,3H-pyrido[2,3-b][1,4]oxazine
SMILES BrC1=CN=C2OCCNC2=C1

Description

7-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine features a brominated pyridooxazine scaffold with enhanced electrophilic character at the C7 position. This bench-stable heterocycle integrates readily into cross-coupling reactions and serves as a strategic intermediate in medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors.

Application

7-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, while the fused oxazine core provides structural rigidity and favorable pharmacophore geometry. The compound exhibits good bench stability and facilitates efficient functionalization in standard synthetic workflows.

Synthesis

Route1
- In-stock
  
  105544-36-3
- ~67%
- In-stock
  
  946121-78-4
References
- Ackermann, Jean; Bleicher, Konrad; Ceccarelli, Simona M.; Chomienne, Odile; Mattei, Patrizio; Sander, Ulrike Obst Patent: US2007/191603 A1, 2007 ; Location in patent: Page/Page column 37 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 34.15
LogP 1.6484
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Key Words

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7-Bromo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine

CAS No. 946121-78-4

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