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Ethyl 2-methyl-2-(4-(4,4,5,5-tetramEthyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate

  • CAS No. 1201657-32-0

  • Cat. No. CS-M2566
  • Purity≥96%
  • MDL No.MFCD18383253

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-methyl-2-(4-(4,4,5,5-tetramEthyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate|CS-M2566

Structure of 1201657-32-0

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General Information

  • CAS No. 1201657-32-0
  • Cat. No. CS-M2566
  • Purity ≥96%
  • MDL No. MFCD18383253
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₅BN₂O₄
  • Molecular Weight 308.18
  • Synonym(s) ethyl 2-Methyl-2-(4-(4
  • SMILES CC1(C)C(C)(C)OB(C2=CN(C(C)(C(OCC)=O)C)N=C2)O1

Description

Ethyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate features a sterically shielded boronate ester paired with a pyrazole heterocycle, enabling reliable coupling in Suzuki-Miyaura reactions. This bench-stable reagent integrates seamlessly into complex molecule assembly workflows.

Application

Ethyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanoate serves as a versatile boronate building block for palladium-catalyzed cross-coupling reactions. The pyrazole moiety enables efficient functionalization in Suzuki-Miyaura coupling, while the sterically hindered tetramethylboronate group ensures high stability and compatibility with diverse reaction conditions. This reagent facilitates rapid access to substituted pyrazole scaffolds commonly found in medicinal chemistry and agrochemical research.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   62.58
  • LogP   1.4805
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   4

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